Session Type: ePosters
Session Title: ePosters
Authors(s): I.D. Olaru (1, 2), R.A. Ferrand (1, 2), M. Chisenga (2), S. Yeung (1), B. Macrae (3), P. Chonzi (4), R.A. Stabler (1), H. Hopkins (1), D. Mabey (1), K.P.E. Masunda (4), K. Kranzer (1, 2)
Authors Affiliations(s): (1) London School of Hygiene and Tropical Medicine, United Kingdom, (2) Biomedical Research and Training Institute, Zimbabwe, (3) UCLH NHS Foundation Trust, United Kingdom, (4) Department of Health, Harare City Council, Zimbabwe
Background:
People living with HIV may be at increased risk for infections with resistant organisms. Infections with extended-spectrum beta-lactamase (ESBL)-producing organisms are of particular concern because they dramatically limit treatment options for severe Gram-negative infections in low- and middle-income settings where alternatives may not be available.
This study aimed to investigate the association between HIV status and urinary tract infections with ESBL-producing E. coli.
Methods:Adults presenting with urinary tract infection (UTI) symptoms to primary care clinics in Harare, Zimbabwe were included in the study. Demographic and clinical data were collected during interviews and a urine sample was collected for culture from each participant. Antimicrobial susceptibility testing was performed according to EUCAST recommendations.
Results:Of the 1164 who were enrolled into the study, 783 (64%) were female and 387 (33%) were HIV-infected. The median age was 35.8 years. Urine cultures were positive in 338 (29.0%) participants, and the majority of bacterial isolates were E. coli (n=254, 75.2%). The presence of ESBL was confirmed in 49/254 (19.3%) E. coli. Participants with HIV had a 2.13 (95% CI 1.05-4.32) higher odds of infection with ESBL-E. coli than individuals without HIV. Also, the prevalence of resistance to most antimicrobials was higher among participants with HIV (Figure 1).
Conclusions:This study found an association between HIV and ESBL-E. coli in patients presenting with symptoms suggestive of UTI to primary care in Harare. HIV status should be considered when prescribing empiric antimicrobial treatment to ensure effective treatment for both in- and outpatients.
Keyword(s): AMR, antimicrobial resistance, ESBLSession Type: ePosters
Session Title: ePosters
Authors(s): I.D. Olaru (1, 2), R.A. Ferrand (1, 2), M. Chisenga (2), S. Yeung (1), B. Macrae (3), P. Chonzi (4), R.A. Stabler (1), H. Hopkins (1), D. Mabey (1), K.P.E. Masunda (4), K. Kranzer (1, 2)
Authors Affiliations(s): (1) London School of Hygiene and Tropical Medicine, United Kingdom, (2) Biomedical Research and Training Institute, Zimbabwe, (3) UCLH NHS Foundation Trust, United Kingdom, (4) Department of Health, Harare City Council, Zimbabwe
Background:
People living with HIV may be at increased risk for infections with resistant organisms. Infections with extended-spectrum beta-lactamase (ESBL)-producing organisms are of particular concern because they dramatically limit treatment options for severe Gram-negative infections in low- and middle-income settings where alternatives may not be available.
This study aimed to investigate the association between HIV status and urinary tract infections with ESBL-producing E. coli.
Methods:Adults presenting with urinary tract infection (UTI) symptoms to primary care clinics in Harare, Zimbabwe were included in the study. Demographic and clinical data were collected during interviews and a urine sample was collected for culture from each participant. Antimicrobial susceptibility testing was performed according to EUCAST recommendations.
Results:Of the 1164 who were enrolled into the study, 783 (64%) were female and 387 (33%) were HIV-infected. The median age was 35.8 years. Urine cultures were positive in 338 (29.0%) participants, and the majority of bacterial isolates were E. coli (n=254, 75.2%). The presence of ESBL was confirmed in 49/254 (19.3%) E. coli. Participants with HIV had a 2.13 (95% CI 1.05-4.32) higher odds of infection with ESBL-E. coli than individuals without HIV. Also, the prevalence of resistance to most antimicrobials was higher among participants with HIV (Figure 1).
Conclusions:This study found an association between HIV and ESBL-E. coli in patients presenting with symptoms suggestive of UTI to primary care in Harare. HIV status should be considered when prescribing empiric antimicrobial treatment to ensure effective treatment for both in- and outpatients.
Keyword(s): AMR, antimicrobial resistance, ESBL
London School of Hygiene and Tropical Medicine, UK
Session Type: ePosters
Session Title: ePosters
Authors(s): I.D. Olaru (1, 2), R.A. Ferrand (1, 2), M. Chisenga (2), S. Yeung (1), B. Macrae (3), P. Chonzi (4), R.A. Stabler (1), H. Hopkins (1), D. Mabey (1), K.P.E. Masunda (4), K. Kranzer (1, 2)
Authors Affiliations(s): (1) London School of Hygiene and Tropical Medicine, United Kingdom, (2) Biomedical Research and Training Institute, Zimbabwe, (3) UCLH NHS Foundation Trust, United Kingdom, (4) Department of Health, Harare City Council, Zimbabwe
Background:
People living with HIV may be at increased risk for infections with resistant organisms. Infections with extended-spectrum beta-lactamase (ESBL)-producing organisms are of particular concern because they dramatically limit treatment options for severe Gram-negative infections in low- and middle-income settings where alternatives may not be available.
This study aimed to investigate the association between HIV status and urinary tract infections with ESBL-producing E. coli.
Methods:Adults presenting with urinary tract infection (UTI) symptoms to primary care clinics in Harare, Zimbabwe were included in the study. Demographic and clinical data were collected during interviews and a urine sample was collected for culture from each participant. Antimicrobial susceptibility testing was performed according to EUCAST recommendations.
Results:Of the 1164 who were enrolled into the study, 783 (64%) were female and 387 (33%) were HIV-infected. The median age was 35.8 years. Urine cultures were positive in 338 (29.0%) participants, and the majority of bacterial isolates were E. coli (n=254, 75.2%). The presence of ESBL was confirmed in 49/254 (19.3%) E. coli. Participants with HIV had a 2.13 (95% CI 1.05-4.32) higher odds of infection with ESBL-E. coli than individuals without HIV. Also, the prevalence of resistance to most antimicrobials was higher among participants with HIV (Figure 1).
Conclusions:This study found an association between HIV and ESBL-E. coli in patients presenting with symptoms suggestive of UTI to primary care in Harare. HIV status should be considered when prescribing empiric antimicrobial treatment to ensure effective treatment for both in- and outpatients.
Keyword(s): AMR, antimicrobial resistance, ESBLSession Type: ePosters
Session Title: ePosters
Authors(s): I.D. Olaru (1, 2), R.A. Ferrand (1, 2), M. Chisenga (2), S. Yeung (1), B. Macrae (3), P. Chonzi (4), R.A. Stabler (1), H. Hopkins (1), D. Mabey (1), K.P.E. Masunda (4), K. Kranzer (1, 2)
Authors Affiliations(s): (1) London School of Hygiene and Tropical Medicine, United Kingdom, (2) Biomedical Research and Training Institute, Zimbabwe, (3) UCLH NHS Foundation Trust, United Kingdom, (4) Department of Health, Harare City Council, Zimbabwe
Background:
People living with HIV may be at increased risk for infections with resistant organisms. Infections with extended-spectrum beta-lactamase (ESBL)-producing organisms are of particular concern because they dramatically limit treatment options for severe Gram-negative infections in low- and middle-income settings where alternatives may not be available.
This study aimed to investigate the association between HIV status and urinary tract infections with ESBL-producing E. coli.
Methods:Adults presenting with urinary tract infection (UTI) symptoms to primary care clinics in Harare, Zimbabwe were included in the study. Demographic and clinical data were collected during interviews and a urine sample was collected for culture from each participant. Antimicrobial susceptibility testing was performed according to EUCAST recommendations.
Results:Of the 1164 who were enrolled into the study, 783 (64%) were female and 387 (33%) were HIV-infected. The median age was 35.8 years. Urine cultures were positive in 338 (29.0%) participants, and the majority of bacterial isolates were E. coli (n=254, 75.2%). The presence of ESBL was confirmed in 49/254 (19.3%) E. coli. Participants with HIV had a 2.13 (95% CI 1.05-4.32) higher odds of infection with ESBL-E. coli than individuals without HIV. Also, the prevalence of resistance to most antimicrobials was higher among participants with HIV (Figure 1).
Conclusions:This study found an association between HIV and ESBL-E. coli in patients presenting with symptoms suggestive of UTI to primary care in Harare. HIV status should be considered when prescribing empiric antimicrobial treatment to ensure effective treatment for both in- and outpatients.
Keyword(s): AMR, antimicrobial resistance, ESBL